Articles
Comparison of the efficacy and safety of succrosomial iron and elementar iron supplementation to treat iron deficiency and iron deficiency anemia in preschool children (3-6 years): protocol of a randomized clinical trial.
Comparison of the efficacy and safety of succrosomial iron and elementar iron supplementation to treat iron deficiency and iron deficiency anemia in preschool children (3-6 years): protocol of a randomized clinical trial.
Katarzyna Kozikowska; Wojciech Bartmiński; Adam Sybilski
Children are particularly vulnerable to iron deficiency and its consequences. The estimated prevalence of anemia in the world population is about 40%. According to WHO, 47% of preschool children and 25% of school-age children suffer from iron deficiency anemia. Results of ongoing studies indicate that iron deficiency and anemia in children may impair their further development, both neurological and motor. The treatment of choice for iron deficiency and iron deficiency anemia is prolonged administration of oral iron preparations. Iron ions not absorbed from the intestine determine frequent adverse effects, which become a reason to abandon therapy with the prolongation of supplementation. Our study was designed to compare the efficacy of succrosomal and elemental iron supplementation in the treatment of iron deficiency and iron deficiency anemia in children aged 3-6 years by evaluating iron metabolism parameters. We also planned to assess the side effects of the studied supplements, the efficacy of the therapy with a single daily dose and the analysis of the occurrence and subsidence with the supplementation of clinical symptoms of iron deficiency or iron deficiency anemia in children aged 3-6 years. This is the single-center randomized comparative study. A total of 100 patients were planned to be enrolled in the study. Iron supplementation will be administered for 12 weeks. The primary aim of the study is to demonstrate that the effect of the application of succrosomal iron preparation is not worse than in the case of the application of elemental iron. The secondary objectives are to evaluate the adverse effects of the compared preparations, the efficacy of iron supplementation administered in a single daily dose and assess the occurrence and treatment-related resolution of iron deficiency symptoms and iron deficiency anemia in the study population.
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Treatment of cancers with a novel combination of re-purposed pharmaceuticals and nutriceuticals.
Treatment of cancers with a novel combination of re-purposed pharmaceuticals and nutriceuticals.
Reginald Marsh, Tinte Itinteang
A 63 year old woman with CLL Leukemia offered to try a novel treatment being developed at our centre. Beginning with Propranolol and Aliskiren several additional compounds were tried over time, Aspirin, Curcumin and Bromelain were retained. Over the succeeding eight years her lymphocyte count has risen slowly and was presently stable around 35,000. A few weeks ago when Bromelain was increased to 500 mg pd the Lymphocytes dropped to 32.1. The patient still continues to lead a normal life with no side effects, the only complaint being tiredness. This treatment we infer to at, least, inhibit cancer growth.
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What Does Comorbid Status Implication with the End Status of Corona Virus Disease (Covid-19) Patients?
What Does Comorbid Status Implication with the End Status of Corona Virus Disease (Covid-19) Patients?
Melati Noormaulidya Putri, Muhammad Syarif, Iwan Aflanie, Endah Labati S, Fauzie Rahman,...
Background: The prevalence of confirmed cases of Covid-19 is quite high and tends to continue to increase. Based on data, South Kalimantan Province in early mid-2021 experienced a high spike in cases, resulting in a large number of deaths, especially in the City of Banjarbaru. Covid-19 active cases in South Kalimantan in July 2021 were recorded at 5,279 cases (12.41%) out of a total of 42,527 positive cases. Many research results on risk factors for Covid-19 cases, the results vary widely. People with comorbidities are a very vulnerable group. Objective: to analyze whether comorbid status has implications for the final status of Covid-19 patients in inpatients at the Idaman Hospital, Banjarbaru City. Methods: Quantitative research using an observational design through a case-control approach. The population is 300 respondents and the research sample is 60 respondents with a sample group of 30 people and a control group of 30 people. The data used is data from the case form report (CFR). The dependent variable in this study was the final status (died/recovered) in inpatients diagnosed as positive for Covid-19 at the Idaman Hospital, Banjarbaru City, while the independent variables were age, gender, hypertension, diabetes mellitus, pneumonia, heart failure, kidney failure. chronic chronic disease (CKD) and stroke (CVA). Data were analyzed univariately and bivariately with chi-square to obtain adjusted OR. Results: Analysis using the chi-square test showed that chronic kidney failure (p=0, 026) has implications for the mortality status of patients with a risk of dying 10 times compared to patients without comorbidities, and heart disease (p=0.045) with a risk of dying 6 times compared to patients without heart disease. Conclusion: Chronic kidney disease (CKD) and heart disease are the highest risk factors that affect death in patients with Covid-19.
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