Articles
INGUINAL HERNIAS REPAIR BY LAPARASCOPY.(TEP).
INGUINAL HERNIAS REPAIR BY LAPARASCOPY.(TEP).
Dr. Pedro Rolando Lòpez Rodrìguez
Introduction: The hernia affection is one of the processes that has been studied into much detail and whose treatment pursues excellence, although many controversies are still yet to be resolved. Laparoscopy repair of inguinal hernia is a treatment method that improves the quality of management given to our patients.
Objective: To identify perioperative events, surgical complications and
to evaluate the pain referred for the patients who have had inguinal hernia repair by the laparoscopic method. (TEP).
Methods: A prospective and descriptive study was done on 80 patients who have had endoscopic (TEP)repair of inguinal hernias between January 2013 and December 2020.
Results: We performed 100 hernioplastias by laparocoscopy in 80 patients. The male sex predominated in a 5:1 ratio and the surgical time
average was, 53.5 minutes for unilateral hernias and 71.3 minutes for
the bilateral ones. The most frequent complication in the transoperatory stage was ¨minor bleeding¨. At 15 days after surgery, 86.3% of the operated did not complain of pain, but social and laboral reintegration was at a 34% of the total.
Conclusions: Laparoscopic inguinal hernioplasty is a good therapeutic option, mainly in patients with bilateral and reproduced inguinal hernias.
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Identification the hub genes in HL-60 leukemia cells on decitabine through bioinformatics analysis
Identification the hub genes in HL-60 leukemia cells on decitabine through bioinformatics analysis
Fuxue Meng, Lonakuan Li, Qin Zheng
Objective: Aims to identification the hub genes in HL-60 acute myeloid leukemia cells treated with decitabine, provide meaningful insights into the pathogenesis of AML. Methods: The gene expression profile of GSE24224 was obtained from GEO database, GO and pathway enrichment were performed though DAVID, established a PPI network from the STRING database and was displayed through the weight network diagram of omicShare tools. MiRNA targets and RBP targets prediction were carried out to further unravel the functions of hub genes identified. Results: 1558 differentially expressed genes were identified. GO and pathway analyses mainly involved citrulline metabolic process, positive regulation of neutrophil extravasation, positive regulation of cell adhesion molecule production, phospholipase A2 inhibitor activity, hematopoietic cell lineage, TGF-β signaling pathway, p53 signaling pathway. The miRNA and RBP targets prediction hinted that the 10 hub genes identified plays an important role in prognosis of AML. Conclusion: This study intimated that hub genes C3, C3AR1, FPR2, GNA11, PTAFR, ITGAM, ANXA1, LPAR1 CXCR4 and FPR1 identified predictively targeted hsa-miR-520d-5p, hsa-miR-362-5p, hsa-miR-224-5p, hsa-miR-1913, hsa-miR-196b-5, hsa-miR-188-5p, hsa-miR-130a-5p, hsa-miR-204-5p, hsa-miR-211-5p, hsa-miR-671-5p, hsa-miR-296-3p and hsa-miR-23b-3p and ADAR1, DGCR8, DKC1, ELAVL1, FBL, FUS, HNRNPC, IGF2BP2, NOP58, TAF15, U2AF2 and UPF1 proteins may regulate the occurrence and development of AML. This study provides meaningful insights and ideas for further understanding the pathogenesis of AML.
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